Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Potential of Indonesian Herbal Medicine, Phaleria macrocarpa (Scheff.) Boerl, for Targeting Multiple Malignancy Signaling Pathways: An Introductory Overview

A wide variety of natural compounds have been recognized for targeting multiple malignancysignaling pathways and inducing apoptosis in various cancer cell lines from different origins. Thechemical compositions of those substances present in plants contribute to their significantbiological and medicinal value. In this review, we summarized our current findings and knowledge of bioactive compounds isolated from the Indonesian medicinal herb, Phaleria macrocarpa (Scheff.) Boerl, also known as Mahkota Dewa (MaDe) that originated from Papua province. A growing body of evidence from several countries suggests that the plant possesses potential for cancer therapy and chemoprevention. Exploring its mechanism in targeting multiple malignancy signaling pathways will provide valuable information for possible clinical applications in cancer management.