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Effects Of Ethanolic Extracts From Meniran Herbs (Phyllanthus Niruri L.) , Papaya Leaves (Carica Papaya L.), And Red Guava Leaves (Psidium Guajava L.) Against The Numbers Of Platelets, Erythrocytes, And Hematocrytes Level On Female White Rats (Rattus Novergicus ) By Using Heparin Induction Method

Effects Of Ethanolic Extracts From Meniran Herbs (Phyllanthus Niruri L.) , Papaya Leaves (Carica Papaya L.), And Red Guava Leaves (Psidium Guajava L.) Against The Numbers Of Platelets, Erythrocytes, And Hematocrytes Level On Female White Rats (Rattus Novergicus ) By Using Heparin Induction Method
Ami Tjitraresmi, Eli Halimah, Yasmiwar Susilawati, Dhani Adriati Koswara
Universitas Padjadjaran, Faculty of Pharmacy, Universitas Padjadjaran, Proceeding The International Seminar and Expo on Jamu 2010 (ISEJ 2010) “Herbal Medicines : Indigeneous, Molecular Aspects, and Clinical Application” Bandung, Indonesia, 3-6 November 2010, ISBN 978-602-96121-1-0
Bahasa Inggris
Universitas Padjadjaran, Faculty of Pharmacy, Universitas Padjadjaran, Proceeding The International Seminar and Expo on Jamu 2010 (ISEJ 2010) “Herbal Medicines : Indigeneous, Molecular Aspects, and Clinical Application” Bandung, Indonesia, 3-6 November 2010, ISBN 978-602-96121-1-0
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This research is about the effect of ethanol extract of meniran (Phyllantus niruri L.) , papaya leaves (Carica papaya L.), and red guava leaves ( Psidium guajava L.) against the number of platelets, erythrocytes, and hematocrytes level on female white rats (Rattus novergicus ) by using Heparin Induction Method. The meniran ethanol extract dosages used are 125, 250, 500mg/kg BW, the papaya leaves ethanol extract dosages used are 100, 200, 400mg/kg BW; and the red guava leaves ethanol extract dosages used are 250, 500, 1000mg/kg BW. Observation of changed parameters was done after 7 days. The result showed that the ethanol extract of meniran, papaya leaves, and red guava leaves caused a significant increase on the number of platelets, erythrocytes and hematocrytes level compared to the negative control. The result shows that the plant which has significant difference againts negative control on platelets number increasement is ethanol extract of meniran on 250 and 500mg/kg BW dosages, ethanol extract of papaya leaves on 200 and 400mg/kg BW and ethanol extract of red guava on 500 and 1000 mg/kgBW, otherwise the increasement of erytrocytes number and hematocryte’s level which have significant difference againts negative control is ethanol extract of meniran on 125,250, 500mg/kgBW dosages, ethanol extract of papaya leaves on 200 and 400 mg/kgBW dosages, ethanol extract of red guava on 500 and 1000mg/kgBB dosages. The biggest effect which obtained from improvement the amount of platelets that is at dose 500 mg/kg BW (dose III meniran) with percentage 84%, improvement the amount of eritrocytes that is at dose 500 mg/kg BW (dose III meniran) with percentage 32,98%, while improvement rate of hematocrytes at dose 1000 mg/kg BW (dosis III daun jambu biji merah) dengan persentase 10,43%. From result of censorship of fitokimia obtained by compounds of metabolit secunder which implied in extract of ethanol meniran, leaf of papaya and red guava leaf. Ethanol extract of meniran consist of alkaloid, polifenol, tannin, saponin, flavonoid, monoterpen & seskuiterpen, triterpenoid and kuinon.. Ethanol extract of papaya leaf consist of alkaloid, polifenol, tannin, saponin, flavonoid and kuinon. Ethanol extract of guava leaf consist of polifenol, tanin, saponin, flavonoid, monoterpen & seskuiterpen, triterpenoid and kuinon.

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