Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Korelasi Ekspresi Immunositokimia Vascular Endothelial Growth Factor A (Vegf A) Dengan Protein Gene Product 9,5 (Pgp 9,5) Darah Haid Pada Patofisiologi Endometriosis ( Correlation Expression Immunocytochemistry Vascular Endothelial Growth Factor A (Vegf A) With Protein Gene Product 9.5 (Pgp 9.5) Of Menstrual Blood On Pathophysiology Endometriosis)

Terdapat perubahan fenotip molekuler endometrium eutopik pada endometriosis berupa perubahan ekspresi gen, respon terhadap hormone steroid, peningkatan marker inflamasi dan molekul adesi seluler, penurunan indeks apoptosis dan kapasitas desidualisasi, peningkatan marker stress oksidatif, peningkatan aktifitas angiogenesis dan neurogenesis. Penelitian dilakukan untuk menganalisis perbedaan ekspresi faktor angiogenesis (VEGF-A) dan faktor neurogenesis (PGP 9,5) endometrium eutopik darah haid antara penderita endometriosis dengan non endometriosis serta korelasi kedua faktor tersebut. Penelitian ini merupakan penelitian potong silang yang menelaah hubungan antara kejadian endometriosis dengan faktor resiko berupa ekspresi VEGF dan PGP 9,5 didalam darah haid. Terdapat perbedaaan yang bermakna ekspresi immunositokimia VEGF A endometrium eutopik darah haid antara kelompok endometriosis dan non endometeriosis (p=0,002). Terdapat perbedaan yang signifikan ekspresi VEGF A dan PGP 9,5 endometrium eutopik darah haid antara kelompok endometriosis dan non endometriosis. Terdapat korelasi positif antara ekspresi VEGF A dengan PGP 9,5 endometrium eutopik darah haid penderita endometriosis.

There are changes of eutopic endometrium molecular fenotipe in endometriosis such as changes in gene expression, steroid hormone response, increase of inflammation marker and cellular adhesion molecule, decrease of apoptotic index and decidualization capacity, increase of oxidative stress marker, increase activity of angiogenesis and neurogenesis. This study was conducted to analyze the differences in the expression of angiogenic factors (VEGF A) and neurogenesis factors (PGP 9.5) eutopic endometrium of menstrual bleeding among patients with endometriosis and non endometriosis and then the correlation of the two factors. This study is a cross sectional that examines the relationship between the incidence of endometriosis with risk factors such as VEGF expression and PGP 9.5 in menstrual blood. There were significant differences in the expression of VEGF A eutopic endometrium menstrual blood between endometriosis and non endometriosis group (p=0.002). There are significant differences expression of VEGF A and PGP 9.5 eutopic endometrial of menstrual blood between endometriosis and non endometriosis groups. There is a positive correlation between the expression of VEGF A with PGP 9.5 eutopic endometrial of menstrual blood on endometriosis patients.