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Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause

Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause
Rima Yulia Effriyanti, Tita Husnitawati Madjid, Hanom Husni Syam
Universitas Padjadjaran, Journal of Biosciences and Medicines, 2016, Vol. 4, No. 1, ISSN 2327-5081 (Print), ISSN 2327-509X (Online), http://www.scirp.org/journal/jbm, http://dx.doi.org/10.4236/jbm.2016.41016,
Bahasa Inggris
Universitas Padjadjaran, Journal of Biosciences and Medicines, 2016, Vol. 4, No. 1, ISSN 2327-5081 (Print), ISSN 2327-509X (Online), http://www.scirp.org/journal/jbm, http://dx.doi.org/10.4236/jbm.2016.41016,
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Objective: In order to identify the correlation between equol excreted through human urine and the symptom of menopause. Methods: The method used is cross sectional study examined to 99 postmenopausal women fulfilling the inclusion criteria from February 2014 to July 2014. This research was taken in the Endocrinology Clinic, Department of Obstetrics and Gynecology, Hasan Sadikin Hospital and Unpad’s Pharmacokinetic Laboratory. All objects were interviewed using menopause rating scale (MRS) questionnaire. Their urine samples were analyzed using high performance liquid chromatography (HPLC). Then the results of questionnaire and HPLC test were evaluated. Results: The result is 97 objects (98%) detected having menopausal symptoms, produced equol. There is significant correlation between the level of equol in post-menopausal women that showed correlation (-0.71) which mean the higher the equol level, the lower the MRS score (p< 0.001) that mean the symptom is milder. Conclusion: Equol level in menopause women urine is a good predictor to identify the level of menopause symptoms.

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