Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Design and Realization of Semi-Manual Beads Template System to Produce Antibiotic-Loaded PMMA Beads

This article describes the design and realization of a relatively simple template system for antibiotic-loaded polymethylmethacrylate (PMMA) beads to provide good antibiotic release. The template system has been designed to semimanually produce antibiotic-loaded PMMA beads in almost spherical shape and regular diameter of 8 mm. All 30 beads will be tied together by a flexible stainless steel wire 0.8 mm in diameter. The technique and extent of mixing of antibiotic with cement base greatly affects the distribution of drug throughout the cured cement and likely to cause major variations in the amount of drug subsequently released. Mixing of the polymer and antibiotic powder components should be meticulous and in similar light pressure inside the beads. The system consists of a Polytetrafluoroethylene (PTFE) ring as a beads template and a stainless steel ring part as a compression structure. There are 30 holes with a spherical shape inside the PTFE part, to produce 30 almost regular shapes of antibiotic beads. This system should be heated during sterilization in the autoclave and hardening process of polymerization. The experimental results show that this system is able to produce 30 pieces of 8 mm antibiotic beads and connected to each other by a flexible stainless steel wire. In conclusion, by adjusting the PTFE rings and compressed by stainless steel rings can produce good spherical shape beads. Therefore, it is expected that the beads template system will be able to yield good antibioticloaded beads with higher porosity and better antibiotic release.