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Microevolution of Mycobacterium tuberculosis in a Tuberculosis Patient

Microevolution of Mycobacterium tuberculosis in a Tuberculosis Patient
Sahal A M Al-Hajoj, Onno Akkerman, Ida PArwati, Saad al-Gamdi, Zeaur Rahim, Dick van Soolingen, Jakko van Ingen, Philip Supply, Adri G. M. van der Zanden
Universitas Padjadjaran, Journal Of Clinical Microbiology 2010 Oct 48(10), doi : 10.1128/JCM.00556-10
Bahasa Inggris
Universitas Padjadjaran, Journal Of Clinical Microbiology 2010 Oct 48(10), doi : 10.1128/JCM.00556-10

Five Mycobacterium tuberculosis isolates were obtained from three body sites from a Dutch patient. The isolates displayed a single genotype by 24-locus MIRU-VNTR typing (except for a single locus not amplified from one isolate) but were differentiated by small variations in IS6110 fingerprints, spoligotypes, 6 hypervariable MIRU-VNTR loci, and/or DiversiLab profiles, revealing patterns of microevolution in a clonal infection.

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