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Comparison Laser and Combine Laser Bevacizumab in Macular edema due to CRVO

Comparison Laser and Combine Laser Bevacizumab in Macular edema due to CRVO
Arief S Kartasasmita, Siska Takarai, Astriviani Switania, Sutarya Enus
Universitas Padjadjaran, The 120th Annual Meeting of the Japanese Ophthalmological Society 2016
Bahasa Inggris
Universitas Padjadjaran, The 120th Annual Meeting of the Japanese Ophthalmological Society 2016
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Introduction: Macular grid laser photocoagulation remained the standard of care for macular edema secondary to BRVO. But after grid laser photocoagulation the visual acuity improvement is often very limited. More recentlyvascular endothelial growth factor (VEGF) is known to play a major role in this macular edema due to BRVOOne possible strategy for treating macular edema is to inhibit VEGF activity by competitively binding VEGF with anti- VEGF antibody, suggesting therapy with bevacizumab. Purpose: We conducted a comparative prospective study to evaluate increase visual aquity and decrease central macular thickness of combination laser photocoagulation with bevacizumab versus laser treatment of macular edema secondary BRVO. Method Nineteen consecutive patients with macular edema secondary to BRVO were assigned to either 9 patients in combination laser photocoagulation with bevacizumab group or to 10 patients in laser photocoagulation group. Complete ophthalmologic examinations were performed just before tratment and one month after treatment. Changes in logarithm of minimum angle of resolution (logMAR) visual acuity and central macular thickness shown by optical coherence tomography (OCT). Result: Combination laser photocoagulation and intravitreal bevacizumab revealed a significantly better visual acuity compared with laser photocoagulation treatment (0.35 versus 0.13 logMAR; p 0.041) and reduced macular thickness 120,33µm versus 71,50µm (p 0,277). Conclusion : Laser photocoagulation combined with intravitreal bevacizumab has a substantial effect on increasing on visual acuity in macular edema associated with BRVO

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