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Association between Clinical Profiles and Severe Dengue Infection in Children in Developing Country

Association between Clinical Profiles and Severe Dengue Infection in Children in Developing Country
Masayu Amanda Ledika, Djatnika Setiabudi, Meita Dhamayanti
Universitas Padjadjaran, American Journal of Epidemiology and Infectious Disease 2015, Vol. 3, No. 3, Available online at http://pubs.sciepub.com/ajeid/3/3/1, DOl:l0.l2691 /ajeid-3-3- 1
Bahasa Inggris
Universitas Padjadjaran, American Journal of Epidemiology and Infectious Disease 2015, Vol. 3, No. 3, Available online at http://pubs.sciepub.com/ajeid/3/3/1, DOl:l0.l2691 /ajeid-3-3- 1
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Background: Dengue virus infection is endemic and is one of major causes of morbidity and mortality in children. The cause of mortality in children with dengue infection was not limited to shock but also caused by severe bleeding and organ dysfunction. This study aim to to examined clinical profiles of children with dengue infection and their association with severe dengue. Methodology and principal findings: Cross—sectional study of chiidren with dengue virus infection admitted to Department of Child Health, Hasan Sadikin Hospital Bandung from April 2013 to September 2014. Subjects were patient age 1—<14 who fulfilled 2009 WHO criteria for dengue virus infection. Association between clinical profile and severe dengue infection was analyzed in two steps. After bivariate analysis, variable with p value <0.25 was included in the next step by logistic regression. P value <0.05 was consider significant. Of 451 subjects, 24.6% (n=l 11) had severe dengue infection. Dengue shock syndrome with or without other form of severe dengue was the most common complication and occured in 65.7% (n=73) of all severe dengue cases. Patient admitted > 4th day of illness (OR 13.25 95%CI 3.45-50.86), Persistent vomiting (OR 30.32 95%CI 7.41-55.74). hepatomegaly (OR 21.72 95 1 /60 7.73-61.01), platelet count <50.000/mm 3 (OR 26.54 95%CI 8.5981.99), and leukocyte >5000/mm3 at admission (OR 4.25 95%C1 1.55-11.65) were associated with severe dengue infection. Conclusion: Clinical manifestation of severe dengue infection was not limited to dengue shock syndrome. Patient admitted >4th day of illness, persistent vomiting, hepatomegaly, platelet count <50.000/mm3 and leukocyte 25000/mm3 at admission were associated with severe dengue infection in children.

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