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A Novel Of Derivative Spectrophotometry As Rapid And Accurate Method In Application Of Simvastatin Co-crystal Assay

A Novel Of Derivative Spectrophotometry As Rapid And Accurate Method In Application Of Simvastatin Co-crystal Assay
Iyan Sopyan, Achmad Fudhloli, Muchtaridi Muchtaridi, Ika Puspita Sari, Dewi Permatasari
Universitas Padjadjaran, International Journal of Research in Pharmaceutical Sciences 7(4), 301-306, 2016, ISSN: 0975-7538, www.ijrps.pharmascope.org
Bahasa Inggris
Universitas Padjadjaran, International Journal of Research in Pharmaceutical Sciences 7(4), 301-306, 2016, ISSN: 0975-7538, www.ijrps.pharmascope.org
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The objective of this study was to obtain a rapid and valid method of quantitative analysis for the determination simvastatin (SV) in combination with saccharin (SAC) and aspartame (ASP) in the co-crystal form using derivative spectrophotometri c. Co-crystal preparation was conducted using solvent drops grinding (SGD). Samples of each co-crystal of ASP and SAC were dissolved in a solvent mixture of the methanol -water with a ratio (60:40); afterward it was derived using the zero crossing order for determining level of SV. The analytical method was validated based on validati on parameter requirements , including, linearity, range, accuracy, precision, limit of detection (LOD) and the limit of quantitation (LOQ). The derivate spectrometri c method have exhibited the zero crossing order in the third order derivate at 251 nm, linearity studies showed the value r2 =0.9998 in a concentrati on range 0.25-2µg/ml . The accuracy was presented by the %recovery = 98.69%- 103.74%, and preci si on (%RSD) =1.67% -2.96%. LOD and LOQ resul ts presented a val ue 0.096 and 0.32µg/ml , respecti vel y. Deri vati ve spectrophotometri c has been applied to the SV determination in co-crystal form and ful filled all requirement of a method validati on.

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