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Dissolution Rate Repairing of Simvastatin as A New Approach in Cocrystallization

Dissolution Rate Repairing of Simvastatin as A New Approach in Cocrystallization
Ratna Mutia Kharisma, Iyan Sopyan
Universitas Padjadjaran, Scholars Research Library Der Pharmacia Lettre, 2017, 9 [6]:30-39, ISSN 0975-5071, USA CODEN: DPLEB4,[http://scholarsresearchlibrary.com/archive.html]
Bahasa Inggris
Universitas Padjadjaran, Scholars Research Library Der Pharmacia Lettre, 2017, 9 [6]:30-39, ISSN 0975-5071, USA CODEN: DPLEB4,[http://scholarsresearchlibrary.com/archive.html]
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Simvastatin (SV) is a cholesterol-lowering drug of choice classified into a class II of drugs based on bbiopharmaceutical cclassification ssystem (BCS), which is a drug that has a poor solubility but high permeability. Low solubility drug caused a low bioavailability in the blood before it reached its workplace. Cocrystallization is one way to enhance the solubility and dissolution rate of SV with aspartame (ASP) as the conformer. Cocrystals was being examined on its solubility and dissolution test. Afterward, cocrystal was characterized by fourier ttransform iinfrared (FT-IR), X-ray powder ddiffraction (XRPD) and ddifferential scanning ccalorimetry (DSC). Co-crystalline simvastatin with co-former ASP equimolar enhances solubility of simvastatin by 193.28% and it enhances the rate of dissolution by 153.53%. Characterization of the cocrystals shown there were a resultant of functional groups from SV and ASP, and it is also shown a different pattern of the thermogram, and difractogram, consequently, it has indicated the formation of cocrystals.

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