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Solid State Characterization Of A Novel Physical Interaction (Paracetamolchlorpheniramine Maleate)

Solid State Characterization Of A Novel Physical Interaction (Paracetamolchlorpheniramine Maleate)
Iyan Sopyan, Intan Mutiara Sari, Insan Sunan K
Universitas Padjadjaran, International Journal Of Applied Pharmaceutics Vol 10, Issue 1, 2018 , ISSN- 0975-7058 , DOI: http://dx.doi.org/10.22159/ijap.2018v10i1.22840
Bahasa Inggris
Universitas Padjadjaran, International Journal Of Applied Pharmaceutics Vol 10, Issue 1, 2018 , ISSN- 0975-7058 , DOI: http://dx.doi.org/10.22159/ijap.2018v10i1.22840
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Objective: Interactions of active pharmaceutical ingredients (API) as well as pharmaceutical excipients don’t occur in a pharmaceutical dosage form. Base on structures of paracetamol (PCT) and chlorphenamine maleate (CTM), its combination is possible to give a physical interaction in the solid state. This study was conducted to investigate the physical interaction of PCT and CTM in the solid state. Methods: Characterization used the polarization microscope, solubility test, powder x-ray diffraction (PXRD) to observe peak shifting in 2O angle, and fourier transform infrared spectroscopy (FT-IR) to examine wavenumber shifting. Results: Results of solubility exhibited an increased solubility percentage with increasing concentration. Polarization microscope analysis presented a combination of crystal morphology after the two substances were mixed in an equimolar ratio. The result of melting point determination of each pure substance was 172 °C for PCT, 132 °C for CTM, and 170 °C for the mixture of the two substances in various ratios. Diffractogram showed the shifting at angle 2O: 20.715, 19.355-23.500 and 21.840, 26.455-20.330 for concentration ratio of PCT: CTM in (132:0.5) and (330:1) respectively and any change in the functional group was observed from infrared spectrum. Conclusion: All evaluation of PCT and CTM in the solid state has exhibited the interaction in solid condition.

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