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Catechin Isolated From Garcinia Celebica Leaves Inhibit Plasmodium Falciparum Growth Through The Induction Of Oxidative Stress

Catechin Isolated From Garcinia Celebica Leaves Inhibit Plasmodium Falciparum Growth Through The Induction Of Oxidative Stress
Rizky Abdulah, Eka W. Suradji, Anas Subarnas, Unang Supratman, Milyadi Sugijanto, Keri Lestari, Melisa I. Barliana, Shinichiro Kawazu, Hiroshi Koyama, Ajeng Diantini
Universitas Padjadjaran, Pharmacognosy Magazine, Volume 13, Issue 50, April-June 2017 (Supplement 2), DOI: 10.4103/pm.pm_571_16, http://www.phcog.com
Bahasa Inggris
Universitas Padjadjaran, Pharmacognosy Magazine, Volume 13, Issue 50, April-June 2017 (Supplement 2), DOI: 10.4103/pm.pm_571_16, http://www.phcog.com
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Background: Resistance of antimalarial drugs to Plasmodium falciparum has become a major concern in malaria eradication. Although it is also affected by several socioeconomic factors, a new antiplasmodial agent is needed for a global malaria control program. Objective: In this study, we attempted to uncover the antiplasmodial properties of Garcinia celebica, an Indonesian medicinal plant, along with the responsible compound and its possible mechanism. Materials and Methods: The G. celebica leaves were ethanol extracted and fractionated based on their polarity using n-hexane, ethyl acetate, and water. The antiplasmodial activity was tested in vitro against chloroquine-resistant P. falciparum at 100 µg/ml for 72 h. The active compound of the most active ethyl acetate fraction was subsequently isolated using column chromatography and identiied by nuclear magnetic resonance. Results: T h e C of (+)-catechin, the characterized compound, against P. falciparum was 198 µM in 24 h and experiment. The isolated catechin inhibited P. falciparum growth in both trophozoite and schizont stages. An additional experiment also suggests that the antiplasmodial property of catechin occurs through the induction of the oxidative stress to P. falciparum. Conclusion: This result shows that the potential of catechin and its antimalarial properties should be explored further.

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