Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Effect Of Oral Zinc On Hyperbilirubinemia In Full Term Neonates

<p>Background Oral zinc has been shown to reduce serumun conjugated bilirubin in animals, adolescents and low birth weight neonates. However, studies in healthy term neonates given oral zinc showed no reduction in hyperbilirubinemia based on time measurement in days. In order to improve accuracy, hyperbilirubinemia may be determined based on time measurements in hours. Objective To determine the effect of oral zinc on hyperbilirubinemia in full term neonates, based on time measurement in hours, rather than days. MethodsWe conducted a randomized, double-blind clinical trial on healthy term neonates born spontaneously or through elective caesarean section in Hasan Sadikin Hospital from June to July 5 mg of zinc sulphate and those receiving a placebo, sucrose, each and upon follow-up at day 5 of life. Factors which may be related to hyperbilirubinemia such as maternal age, infants’ gender, umbilical cord bilirubin levels and type of feeding, were analyzed by chi-square test. Hyperbilirubinemia persistence and comparison analysis and Logrank test. Results mean duration of hyperbilirubinemia in the 15 subjects in the zinc group and 11 in the placebo group were 116.5 hours and 117.3 hours, respectively. There was no significant difference in 95% CI 111.5 to 122.7). In addition, chi-square analysis of factors which may be related to hyperbilirubinemia showed no significant Conclusions Oral zinc 5 mg twice daily made no significant difference in hyperbilirubinemia duration in full term neonates despite measuring in hours. [Paediatr Indones. 2011;51:107-10].</p>