Abstrak 
Human Papilloma Virus Genotype and the IFNG Susceptibility among Cervical Cancer Patients in Bandung
Edhyana Sahiratmadja, Ani Melani Maskoen, Ramdan Panigoro, Herman Susanto
Universitas Padjadjaran, Presented at International conference on Biomedical Science : Prospect and Challenge of Biomedical Research School of Life Sciences and Technology ITB in Bandung February 27-28 2012
Bahasa Inggris
Universitas Padjadjaran, Presented at International conference on Biomedical Science : Prospect and Challenge of Biomedical Research School of Life Sciences and Technology ITB in Bandung February 27-28 2012
Cervical cancer, HPV genotypes, IFNG +874 T>A
Sever-al persistent infections by high-risk types of human papillomavirus (HPV) have been established as the etiological agent of cervical cancer, with the most prevalent types are HPV-16 and HPV-18. There is a strong evidence that the defense mechanism to HPV is a local response. The majority of the women will clear the infection without overt clinical disease. Those who develop lesions mount an effective cell mediated immune response, and hence the lesions will negress. Interferon gamma (IFN-y) is one of the key regulatory cytokines that influence the HPV dearance. The IFN-y production may be impaired by the IFNG gene dysfunction leading to the cerwical malignant progression. The distribution of IFNG +874T/A polymorphism in gene susceptibility to cervical cancer was analysed. Interestingly, geographical variation in HPV genotypes might have impacted for designing diagnostic tests and vaccine, therefore, early HPV infection detection may minimize the risk of cancer development. However, it has been taken into account that the tests available might yield a different genotype distribution in the population . Our study showed a different result of two commercial kits. In a poor r9source area where HPV genotyping is expensive, a cheaper alternative for HPV genotyping detection might have a beneficial impact.