Pustaka Ilmiah Universitas Padjadjaran

Abstrak

A STUDY OF CYTOMEGALOVIRUS SEROLOGY AMONG HIV-INFECTED PATIENTS IN THE HIGHLY ACTIVE ATIRETROIVIRAL THERAPY ERA

Cytomegalovirus (CMV) is one the most common opportunistic viruses in human immunodeficiency virus (HIV)-infected patients. The aim of this study wasto determine the CMV seroprevalence among HIV-infected patients and investigate the correlation between the CMV immunoglobulin G (IgG) antibody titers and cluster of differentiation 4 (CD4) T-cell counts,as well as highly active antiretroviral therapy (HAART) use. Serum samples from 69 HIV-infected patients and HIV-seronegative persons attending Dr.Hasan Sadikin Hospital Bandung in March-June 2012 were examined to detect CMV IgG antibody using electrochemiluminescence immunoassay (ECLIA). Data were analyzed using chi-square test, t-tes and analysis of variance (ANOVA). The results show that there were no statistically significant differences in the seroprevalence of CMV between HIV-infected (97 %) and HIV-seronegative persons (94 %). The mean of CMVIgG antibodies titers in HIV-infected patients (335.39+174.87 U/mL) were significant chigher than of HIV-seronegative person (240.59+192.76 U/mL). There was no signification between CMVIgG antibody titers and CD4 T-cell counts (the mean was 393.58+209.00 cells/mm3). The titers of CMV IgG antibodies were significantly inversely associated with HAART use. The mean of CMV IgG antibody titers in HIV-infected patients on HAART (204.8+213.9 U/mL). Inconclussion, this study confirms high seroprevalence of CMV among HIV-infected patients. Highttiters of CMV arc inversely associated with HAART use while no correlation with CD4 T-cell count was found