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Heroin use in Indonesia is associated with higher expression of CCR5 on CD4+ cells and lower ex-vivo production of CCR5 ligands

Heroin use in Indonesia is associated with higher expression of CCR5 on CD4+ cells and lower ex-vivo production of CCR5 ligands
Hinta Meijerink, Agnes R. Indrati, Suharyani Soedarmo, Fitri Utami, Cor A.J. de Jong, Bachti Alisjahbana, Reinout van Crevel, Andre J.A.M. Van der Ven, Rudi Wisaksana
Universitas Padjadjaran, Research Letter AIDS 2015, 29:385–388, Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. ISSN 0269-9370 Copyright Q 2015 Wolters Kluwer Health, Inc. All rights reserved., DOI:10.1097/QAD.0000000000000564
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Universitas Padjadjaran, Research Letter AIDS 2015, 29:385–388, Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. ISSN 0269-9370 Copyright Q 2015 Wolters Kluwer Health, Inc. All rights reserved., DOI:10.1097/QAD.0000000000000564
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Opioid use may affect HIV infection through altered expression of HIV co-receptors. This was examined in Indonesia among antiretroviral therapy-naive HIV patients, many of whom use drugs. C-C chemokine receptor type 5 (CCR5) expression on CD4+ cells was higher in heroin (PU0.007), methadone (PU0.024) and former opioid users (PU0.003) compared to nonusers, whereas production of RANTES and other CCR5 ligands was similar or lower. This suggests that opioids can affect HIV susceptibility through up-regulation of CCR5 or down-regulation of its ligands.

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