Abstrak 
New Cytotoxic Protolimonoids From The Stem Bark Of Aglaia Argentea (Meliaceae)
Kindi Farabi, Desi Harneti, Nurlelasari, Rani Maharani, Ace Tatang Hidayat, Khalijah Awang, Unang Supratman, Yoshihito Shiono
Universitas Padjadjaran, Phytochemistry Letters 21 (2017) 211–215, journal homepage: www.elsevier.com/locate/phytol, https://dx.doi.org/10.1016/j.phytol.2017.07.006
Bahasa Inggris
Universitas Padjadjaran, Phytochemistry Letters 21 (2017) 211–215, journal homepage: www.elsevier.com/locate/phytol, https://dx.doi.org/10.1016/j.phytol.2017.07.006
Aglaia argentea, Argentinin A and B, Cytotoxic activity, Protolimonoid, triterpenoid
Two new protolimonoid compounds, namely, argentinin A (1) and B (2) along with ?ve known triterpenoid compounds, dammar-24-en-3a-ol (3), 3-epi-cabraleahydroxy lactone (4), (E)-25-hydroperoxydammar-23-en3ß,20-diol (5), mixture of eichlerianic acid and shoreic acid (6a and 6b), and dammar-24-en-3a,20-diol (7), were isolated from the stem bark of Aglaia argentea. The structure of new compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis. All of the compounds were tested for their cytotoxic efects against P-388 murine leukemia cells in vitro. Among those isolated compounds, argentinin A (1) showed the strongest activity with an IC 50 value of 1.27 µg/mL (3.05 µM).