Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Development Of Phytopharmaca Product Content Of Combination Of Extract Celery ( Apium Graveolens L ) And Sambiloto ( Andrographis Paniculata Ness) As Medicine For Nephrolitiasis

Herbal Medicine has been accepted in all over the world, either in the developing country or developed country. According WHO report about 65% of population in developed country and 80% of population in the developing countrys use herbal medicine. Rising use of herbal medicine in developed countries might be due to increase of life expectancy when prevalent of chronic deseases increase, occurences of failures of medication of modern drug for certain deseases, and widespread of information about herbal medicine in the world. A study on ethanol extract of Celery (Apium graviolens L) and Sambiloto (Andrographis paniculata Ness) herbs was aimed at finding new alternative medicine for Nephrolitiasis. In Vitro preclinical test was carried out to examed solubilizing and dissolving capacity of the extract on calcium, magnesium and uric acid . While in vivo test was done by an induction method on hidroxyprolin on male mice. Formulation of the combination of the two extract to be a suspension dosage form was examined for its stability and quality. The results of the test on its activity the suspension dosage form of the extract effectively reduced nephrolitiasis at dose 2 (combination of sambiloto extract 500 mg/kg BW and celery extract 200 mg /kgBW mice). The dose 3 had faster onset of action and longer duration of action as compared with dose 1, dose 2 and control. Among all dosage forms, the formula with the concentration of CMC 1 % had better pH stability, particle diameter, viscocity, redispersiblity and significant effect on nephrolitiasis.