Pustaka Ilmiah Universitas Padjadjaran

Abstrak

The Evaluation Of Currently Used Home-Made Antimicrobial Linked To Polymethylmethacrylate (Pmma) Beads For The Prevention And Treatment Of Chronic Bone Infection

Infection of bone tissue, or osteomyelitis, is very difficult to cure a reason why stringent prevention is indicated. Currently antibiotic-impregnated polymethylmethacrylate (PMMA) beads are widely used. Placed in the surgical wound, they function as a slow release system to obtain a high local concentration of antibiotic while systemic concentrations remain low. This delivery system is clinically accepted as the method of choice for the treatment of chronic osteomyelitis as well as prophylaxis of deep infection. Therefore, new approaches for prevention and treatment of deep infections are urgently needed in considering cost effective and high effective in killing the microorganisms. We proposed the usage of BME-ITB beads by definition is an antibiotic loaded beads in home-made, mixtures antibiotic (fosfomycin sodium) with the artificial resin PMMA. The purpose of the study is to evaluate currently used home-made antibiotic-loaded beads. First, under sterile conditions, eight different types of hand-made fosfomycin sodium-loaded bone cement bead sets are built in spherical shape. The sizes of beads are varies between 10 and 20 mm. A first evaluation will include a laboratory study on the antibiotic release kinetics, as well as a scanning electron miscroscopic (SEM) evaluation of the porosity and a quantification of the porosity using mercury-intrusion porosimetry. Personal Computer (PC) is used to simulate the porosity of the beads. We may conclude that beads having 10 mm in diameter revealed to more homogeneous pores. The concept of BME-ITB beads by using bone cement as a depot for antibiotic make sense, as it allows delivery of antibiotics directly to the site of infection.