Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Sensitivity Test Cefoxitin (Second Generation Of Cephalosporin) And Cefepime (Fourth Generation Of Cephalosporin) Towards Methicillin Resistant Staphylococcus Aureus (MRSA)

MRSA is known as multidrug resistant bacteria that are resistant towards many antibiotics. These bacteria are also considered as the bacteria that cause sepsis which may lead to death. To manage sepsis condition, an antibiotic agent that is still sensitive towards MRSA is needed. There are some antibiotics that are still presumably sensitive towards MRSA including, among others, Cefoxitin and Cefepime. The objective of this study is to analyze the sensitivity of MRSA towards Cefoxitin and Cefepime in order to get scientific information on the effectiveness of the two antibiotics to be used in the management of sepsis patients. This study is a laboratory experimental study with 40 isolates of methicillin resistant Staphylococcus aureus collected from several hospitals in Bandung to define MRSA bacteria. The method used for sensitivity testing is the agar diffusion method. The result of the sensitivity test is the clear area around the antibiotic disc which is then measured. The Cefoxitin sensitive MRSA bacteria have an inhibition area of >18 mm while the resistant bacteria have an inhibition area of < 14 mm. The same is also true for Cefepime sensitive bacteria. In this study, 1 isolate is resistance, 33 isolates present Cefoxitin sensitive MRSA, i.e. 82.5%, while 100% of them are sensitive towards Cefepime. It is concluded that the growth of MRSA can be considered as being inhibited by Cefoxitin, which is the second generation of Cephalosporin.