Abstrak 
Decoct, Sonchus arvensis L., subchronic toxicity, toxicity test
Diah Dhianawaty D.
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Inggris
Decoct, Sonchus arvensis L., subchronic toxicity, toxicity test
The decoction of Sonchus arvensis leaves has been proved that has anticalculi activity on male rats. The objective of the research is to evaluate the toxic effect of the decoction with repeated dosages during 90 days on female rats.
Female rat divided into four groups, with each group has 10 rats. All of the groups were administered orally with 2 ml solution. The control group received 2% Arabic gum solution, while the treated groups received decoction with the dosages of 0.65; 1.30 and 2.60 mg/kg body weight respectively. The biochemical parameters of the rat’s blood and macropathology organs were measured. All data were analyzed statistically.
The average of GOT, GPT, creatinine clearance, total bilirubin, urea nitrogen, hearts, livers, kidneys, spleens, and ovaries of treated rats are different with control group. All of the result are not statistically significant as P>10.
In conclusion, decoction of Sonchus arvensis leaves is relative safe to be given orally in the repeated dosages during 90 days.