Abstrak 
Supplementary Information A novel susceptibility locus for tuberculosis on chromosome 11p13 downstream the WT1 gene
Thorsten Thye, Ellis Owusu-Dabo, Fredrik O. Vannberg, Reinout van Crevel, James Curtis, Edhyana Sahiratmadja, Yanina Balabanova, Christa Ehmen, Birgit Muntau, Gerd Ruge, Jürgen Sievertsen, John Gyapong, Vladyslav Nikolayevskyy, Philip C. Hill, Giorgio Sirugo, Francis Drobniewski, Esther van de Vosse, Melanie Newport, Bachti Alisjahbana, Sergey Nejentsev, Tom H.M. Ottenhoff, Adrian V.S. Hill, Rolf D. Horstmann, Christian G. Meyer
Universitas Padjadjaran
Bahasa Inggris
Universitas Padjadjaran
chromosome 11p13, tuberculosis, WT1 gene
TB patients were enrolled in Ghana, West Africa, between September 2001 and July 2004 at Komfo Anokye Teaching Hospital in Kumasi, and Korle Bu Teaching Hospital in Accra as well as at additional hospitals/outpatient departments in Accra and Kumasi and at regional district hospitals. The case group consisted of 2146 individuals with a median age of 32 years. The proportion of males was 66.7%. Phenotyping of patients included documentation of major TBrelated symptoms on structured questionnaires, medical histories and physical examination, HIV-1/2 testing (Capillus, Trinity Biotech, Bray, Co Wicklow, Ireland), posterior-anterior chest Xrays, Ziehl-Neelsen staining of two independent sputum smears, and culturing of M. tuberculosis complex isolates on solid Loewenstein-Jensen medium. All cases were HIV-negative and presented with characteristic radiological lesions of pulmonary TB assessed by two independent radiologists. The patients were treated in the framework of the DOTS programme (Directly Observed Treatment Short-Course strategy) organized by the Ghanaian National Tuberculosis Programme.