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Tc-99m MIBI Scintigraphy In Follow-up Of Post-therapy Differentiated Thyroid Carcinoma (DTC)

Tc-99m MIBI Scintigraphy In Follow-up Of Post-therapy Differentiated Thyroid Carcinoma (DTC)
Yudistiro R, Kartamihardja AHS, Masjhur JS
Universitas Padjadjaran, Poster Presentation 4th International Conference on Radiopharmaceutical Therapy New World Hotel, Ho Chi Minh City, Vietnam 28 Nov – 2 Dec 2011
Bahasa Inggris
Universitas Padjadjaran, Poster Presentation 4th International Conference on Radiopharmaceutical Therapy New World Hotel, Ho Chi Minh City, Vietnam 28 Nov – 2 Dec 2011
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Background. Long terms follow-up should be performed in post-therapy DTC patients by measuring serum thyroglobulin (Tg-off) and Thyroglobulin-antigen antibody (AbTg) level in stimulating TSH level every 6-12 months. NaI-131 scintigraphy is done to detect location of remnant thyroid and/or metastases.1 NaI-131 scintigraphy has several disadvantages, such as patient’s discomforts and stunning effect. 99mTc-methoxyisobuthyisonitrile (MIBI) is routinely used as tumor seeking agent; the advantages of 99mTc-MIBI scintigraphy in follow-up of post-therapy DTC patients is still controversy. Diagnostic performance of imaging can be measured by image resolution which is resulted from uptake ratio. Objective. To evaluate the uptake ratio and diagnostic value of 99mTc-MIBI and NaI-131 scintigraphy using Tg-off level as gold standard. Methods. 99mTc-MIBI and NaI-131 scintigraphy were done in 56 patients post-total thyroidectomy and radiothyroablation with NaI-131 who underwent follow up. Maximum counts activity was analyzed from region of interest (ROI) of lesion and background to measure uptake ratio. Background ROI was made in thigh projections. Conclusion. 99mTc-MIBI scintigraphy is not better than NaI-131 scintigraphy by using Tg-off as gold standard. NaI-131 scintigraphy is still the best methood in follow-up of post-therapy DTC patients.

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