Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Correlation between Central Venous Oxygen Saturation (Scv02) and Serum Lactate in Resuscitation of Severe Abdominal Sepsis Using Early Goal Directed Therapy Protocol

Introduction. Intraabdominal infection with severe sepsis is followed with high mortality. Sepsis leads to imbalance of systemic oxygen delivery and oxygen demand, resulting in global tissue hypoxia and anaerobic metabolism. A more definitive resuscitation strategy applies early goal directed therapy (EGDT) to achieve a balance between systemic oxygen delivery and oxygen demand within 6 hours. Central venous oxygen saturation has been shown to be a surrogate for the cardiac index as a target for hemodynamic therapy. Serum lactate is considered to be the end product of anaerobic metabolism. There’s question whether arterial lactate can be alternative measure to replace Scv02. The purpose of a study is to find out the correlation between Scv02, and serum lactate in severe septic patient due to intraabdominal infection. Method. A study was run with cohort prospective quasi experimental, Scv02 and serum lactate were measured every two hours in EGDT period. The results were colerrated with Pearson’s Correlation. Results. There were 35 severe septic patients due to intraabdominal infection. Sixty three percents were male. majority ranged of 51-60 years old. 57% admissions to hospital after had 1-3 days abdominal pain. Fourty six percents ofthe patients were due to peptic ulcer perforation. Mortality rate was 43%. Mean of serum lactate level were decreased from 3.95 to 3.05 in 6 hours resuscitation. Otherwise, mean of Scv02 were found increased from 65.1% to 77.75% in 6 hours. Pearson’s correlation between Scv02, and serum lactate is 0.218. Conclusion. There was a weak correlation between Scv0, and serum lactate in severe sepsis due to intraabdominal infection that achieved EGDT resuscitation. Serum lactate cannot replace Scv02