Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Anti-inflammatory and Analgesic Activities of Mimosa Pudica L. Herb Extract

WHO has recognized herbal medicine as an essential building block for primary health care in Asia. Traditionally, herbs of Mimosa pudica L. are being used to treat various symptoms, e.g. insomnia, hematuria, inflammation, emesis, dismenorrhoea, menorrhagia, arthritis rheumatoid, convulsion, depression, and diabetes. Previous in vitro study showed that herbs extract of Mimosa pudica L reduced uric acid formation via xanthine oxidase inhibition of 82.11 and 62.10% for concentration 125 and 62.5 µg/mL, respectively. This study was performed to study anti-inflammatory and analgesic activities of Mimosa pudica L .herb extract on rodents. Anti-inflammatory activity assay was done using carageenan-induced paw edema method on white male rats. Dosages used were 250, 500 and 1000 mg/kg of body weight. The results showed that all three dosages inhibited edema at the percentages of 35.20, 42.74, and 51.10% respectively. Analgesic activity of Mimosa pudica L herb extract at dosage of 125, 250 and 500 mg/kg of bodyweight was observed on mice using writhing reflex method withaceticacid0,07 % as inducer. The results showed that all three dosages inhibited pain at the percentage of 9.58, 45.35, and 60.28% respectively. It is concluded that herbs extract of Mimosa pudica L can be proposed as anti-inflammatory and analgesic agents.