Abstrak 
INTERACTION OF ASPARTYL-DIPEPTIDES DERIVATIVES WITH METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) USING MOLECULAR DOCKING SIMULATION
Muchtaridi Muchtaridi, Siti Farhain Binti Amir, Wiwiek Indriyati, and Ida Musfiroh
Research Journal of Pharmaceutical, Biological and Chemical Sciences
Inggris
Muchtaridi Muchtaridi, Siti Farhain Binti Amir, Wiwiek Indriyati, and Ida Musfiroh, Research Journal of Pharmaceutical, Biological and Chemical Sciences
aspartame, aspartile-dipeptide, docking, sweetener
Aspartame (L-alpha-aspartil-L-phenylalanine-1-methyl ester) known as a molecule that plays role in sweet taste and the derivatives of aspartile-dipeptide is also known to have the potential as a sweetener. The object of this study was to know the interaction of the aspartyl-dipeptides derivatives against metabotropic glutamate receptors (mGluR). This target protein can induce active synapse signal for a sweet taste. The study has been carried out to observe the interaction of ligand and target protein using molecular docking simulation. The interaction of the aspartyl-dipeptides derivatives connected with Lys409 through hydrogen bond interaction. The carboxylate group might be responsible in the sweetening interacted with Ser186, Thr188, Asp318, Lys409, and Arg78, and N-H group interact with Ser186 and Asp318 favorably by forming hydrogen bond. The benzene ring could interact with Tyr74 and Tyr236 with hydrophobic pocket at the binding site.