Abstrak 
An Overview Sub Chronic Toxicity Test Of Analgesic Jatropha Curcas L. Latex
Irmaleny , Narlan Surnawinata , Dewi Fatma , Marline Abdassah
Universitas Padjadjaran, presented at: REGIONAL BIOMATERIALS SCIENTIFIC MEETING 2010 (RBSM 2010) In Conjunction with 8th Students Scientific Conference (8th SSC) 29 — 30th October 2010, Kota Bharu, Kelantan, Malaysia
Bahasa Inggris
Universitas Padjadjaran, presented at: REGIONAL BIOMATERIALS SCIENTIFIC MEETING 2010 (RBSM 2010) In Conjunction with 8th Students Scientific Conference (8th SSC) 29 — 30th October 2010, Kota Bharu, Kelantan, Malaysia
Jatropha curcas L latex, sub chronic toxicity test
Objectives. Dental pain is a common illness suffered by the society. One of the plants that commonly used for dental pain relief is the latex of Jatropha curcas L. Scientific data regarding analgesic effect of Jatropha curcas L. latex has been widely studied, but there was no scientific data about the safety of its use. The aim of this study was to obtain data on sub chronic toxicity test. Methods. Twenty Wistar strain were divided into four groups (five each). The first group (control – male) and the second group (control — female) were given PGA 2%). The third group (male) and the fourth group (female) were given 1000 mg latex/kg body weight. The parameters measured were urine, blood characteristics (erythrocytes, leukocytes, hematocrytes, haemoglobin), blood biochemistry, index and histopathological data of liver and kidney organ, and peptic ulcer. Results. There were signicifant differences between test and control group (P <0.05) on body weight (male and female), level of haemoglobin and amount erythrocytes (male), index of kidney organ (male and female). There were a few changes in liver and kidney organ of female mouse histopathologically Conclusion. The latex of Jatropha curcas L. in general happened light damage