Abstrak 
Development Eudragit ® L 100-55 Nanoparticle Carrier Based With Curcumin As an Active Ingredients
Marline Abdassah, Dolih Gozali, Rida Rufaidah
Universitas Padjadjaran, Paper Presenter : The 24TH Federation of Asian Pharmaceutical Association (FAPA) Congress 2012, Bali, 13-16 September 2012, Bali Nusa Dua, Indonesia
Bahasa Inggris
Universitas Padjadjaran, Paper Presenter : The 24TH Federation of Asian Pharmaceutical Association (FAPA) Congress 2012, Bali, 13-16 September 2012, Bali Nusa Dua, Indonesia
Curcumin, Eudragit L 100-55, nanoparticle
In recent years, the development of innovative drug carrier system has done to address the problem of poor solubility of the active substance. One of them is polymer based nanoparticle carrier system wich can improve the solubility and bioavailability of a substance due to nanometer size. In this research, Nanoparticles prepared by the bottom up methode, with the polymer dispersion. Formulation ncmoparticles carrier system has made with polymer Eudragit L 100-55 (120 mg, 220 mg, 320 mg), 0.5% PVA solution (w / v) 300 ml in distilled water and 30 ml 95% ethanol. Then characterized using particle size analyzer (PSA) results the smallest size in formula 1 (120 mg Eudragit L 100-55), 83.8 ± 21.9 nm. Once added curcumin (12 mg, 15 mg, 20 mg) in formula 1, the smallest size available on formula 4 (curcumin 12 mg), 104.7 ± 26.4 nm with entrapment efficiency 98.68%. Meaning, the entrapment of curcumin by polymer has been going well.