Abstrak 
Inhibitory activity On uric acid formation by Mimosa pudica tablets
Sri Adi Sumiwi, Marline Abdassah, Raisa Muthiarani, Kirthika Gopal Krishnan, Restri Akhsanitami, Ade Zuhrotun, Jutti Levita
Universitas Padjadjaran, Thai Journal of Pharmaceutical Sciences (TJPS) 2016, ttp://www.tjps.pharm.chula.ac.th/ojs/imdex.php/tjps/author/submission/206
Bahasa Inggris,
Universitas Padjadjaran, Thai Journal of Pharmaceutical Sciences (TJPS) 2016, ttp://www.tjps.pharm.chula.ac.th/ojs/imdex.php/tjps/author/submission/206
allopurinol, gout, hyperurisemic, xanthine, xanthine oxidase
Mimosa pudica L. (Family Mimosaceae or Fabaceae) has been proven in reducing uric acid level. Previous work of Nguyen and colleagues concluded that the methanol extract of this plant showed inhibitory activity on xanthine oxidase (IC50 52.7 ppm), therefore this extract could be developed as pharmaceutical dosage form and assayed for its activity. In this work we developed Mimosa pudica L. tablets using VivapurOPH102 and studied the inhibitory activity of the tablets on uric acid formation by measuring its absorbance at 292 nm. Ex vivo study was performed by measuring the concentration of uric acid in oxonic calcium and chicken liver juice induced-mice blood after the mice were treated with Mimosa pudica L. extract tablets. Allopurinol was used as drug control. Mimosa pudica L. extract tablets containing the highest VivapurePH102 (86%) showed the shortest disintegration time (1 minute 40 seconds). The tablets inhibited uric acid formation (IC50 of Mimosa pudica tablet = 5.381 ppm, IC50 of the extract = 3.5202 ppm). Its inhibitory activity is weaker than allopurinol (IC50 of allopurinol = 2.181 ppm). Ex vivo study showed that Mimosa pudica L. extract tablets 125 mg/kg of body weight reduced 36% of uric acid level in hyper-urisemic mice (a=0.05).