Abstrak 
Propranolo Hydrochloride Controlled Release Formulation Using Hydroxyprophyl Methyleelullose (HPMC) and Ethyl Celullose (EC) Combination as A Matrix With Direct Compress Method
Richie A.I. Chandra, Marline Abdassah , Syarifah Adibah
Universitas Padjadjaran, Presented in International Seminar of Pharnaceutical Science and Technology, September 18-19, 2014, Jatinangor, West Java, Indonesia
Bahasa Inggris
Universitas Padjadjaran, Presented in International Seminar of Pharnaceutical Science and Technology, September 18-19, 2014, Jatinangor, West Java, Indonesia
direct compression, Dissolution test, in process control, Propranolol hydrochloride, sustained release
Propranolol hydrochloride has a short half-life approximately 3-6 hours and low bioavailability. To overcome this problem, the aim of this study was to formulate a sustained release tablet of propranolol hydrochloride using the combination of the concentration of hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC). The tablet were made using a direct compression method. The ratio of percentage of HPMC and EC used were F1 10%: 10%, F2 12.5%: 12.5%, F3 15%: 15% and F4 17.5%: 17.5%. Prepared formulations were subjected to in process control and dissolution test. For the first hour of dissolution test, media of 0.1N HC1 ( pH 1.2) was used, followed by phosphate buffer (pH 7.5) for next 11 hours. It was observed that all the formulation meets the requirement for the IPC test. The drug release of F1 for 1st, 3rd, 6th and 12th hours were 21,14%, 41,61%, 62,03% and 89,47% followed by F2, 15.18%,.34.48%, 57.84%, and 82.95%, F3 15.18%, 33.57%, 50.82%, and 82.33, F4 were 15,56%, 31,35%, 47,18%, and 78,21%.In conclusion formula that meets the requirements of USP 36 were formula 2 with concentration12.5%: 12.5% and 3 with concentration 15%: 15%