Abstrak 
Virtual Screening Of Coformers For Atorvastatin Co-Crystallization And The Characterizations Of The Co-Crystals
D. Gozali, S. Megantara, J. Levita , H.H. Bahti, S.N. Soewandhi, M. Abdassah
Universitas Padjadjaran, IJPSR, 2016; Vol. 7(4): 1450-1455. E-ISSN: 0975-8232; P-ISSN: 2320-5148 (downloaded as mol fonnat from www.chemspider.com)
Bahasa Inggris
Universitas Padjadjaran, IJPSR, 2016; Vol. 7(4): 1450-1455. E-ISSN: 0975-8232; P-ISSN: 2320-5148 (downloaded as mol fonnat from www.chemspider.com)
aspartame, Cholesterol, co-crystallization, HMG CoA-reductase, Hypercholesterolemia, Statin
Atorvastatin calcium (ATC) is very slightly soluble in water and it is classified under BCS class II drugs. A widely used method to enhance the solubility of drugs is co-crystallization. In this work, we screened six co-formers for ATC by employing molecular docking method. The work was continued by co-crystallization process using slurry method, solubility assay of the mixtures using HPLC, and characterization of the co-crystal by PXRD, DSC and SEM. Based on molecular docking, the best co-former is aspartame (Ei = -4.70 kcal/mol). The docking result fits the solubility assay of the ATC-aspartame co-crystal (136.77% increasing of solubility compared to ATC). ATC¬aspartame co-crystal shows better dissolution profile (91.62 % in 60 minutes) than ATC (73.54 % in 60 minutes). The characteristic peaks of ATC and aspartame were gone, whilst new peaks appeared after slurry process. The ATC-aspartame characterization by PXRD, DSC and SEM positively confirmed that the co-crystallization of ATC-aspartame using slurry method was successful.