Abstrak 
A TOTAL SYNTHESIS OF A HIGHLY N-METHYLATED CYCLODEPSIPEPTIDE [2S,3S-HMP]-AUREOBASIDIN L USING SOLID-PHASE METHODS
A TOTAL SYNTHESIS OF A HIGHLY N-METHYLATED CYCLODEPSIPEPTIDE [2S,3S-HMP]-AUREOBASIDIN L USING SOLID-PHASE METHODS
Rani Maharani, Robert T.C. Brownlee, Andrew B. Hughes, Belinda M. Abbott
ELSEVIER
Inggris
Rani Maharani, Robert T.C. Brownlee, Andrew B. Hughes, Belinda M. Abbott, ELSEVIER
Aureobasidin, Depsidipeptide, Fmoc-based solid-phase peptide synthesis, N-Methylated cyclodepsipeptide
Rani Maharani, Robert T.C. Brownlee, Andrew B. Hughes, Belinda M. Abbott
ELSEVIER
Inggris
Rani Maharani, Robert T.C. Brownlee, Andrew B. Hughes, Belinda M. Abbott, ELSEVIER
Aureobasidin, Depsidipeptide, Fmoc-based solid-phase peptide synthesis, N-Methylated cyclodepsipeptide
[2S,3S-Hmp]-Aureobasidin L 2 has been successfully synthesised through a combination of solution- and solid-phase peptide synthesis. All of the Fmoc-protected residues including a depsidipeptide, FmocMeVal-Hmp-OH, were prepared in solution phase. Chain elongation on chlorotrityl resin was undertaken using selected coupling reagents including HBTU/HOBt, HATU/HOAt and BTC/collidine. Cleavage of the linear depsinonapeptide was followed by cyclisation to give the desired cyclodepsipeptide.
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