Pustaka Ilmiah Universitas Padjadjaran

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Korelasi Kadar Malonildialdehid Dan Skor Child Autism Rating Scale Pada Anak Gangguan Spektrum Autisme

Pendahuluan: Tujuan dari penelitian ini adalah untuk menganalisis perbedaan kadar malonildialdehid (MDA) serum sebagai biomarker stres oksidatif pada anak dengan gangguan spektrum autisme (GSA) dan anak normal (nonGSA), serta untuk menganalisis korelasi antara kadar MDA serum anak GSA dengan skor Child Autism Rating Scale (CARS) yang digunakan untuk menilai derajat keparahan GSA. Metode: Penelitian ini adalah kasus kontrol yang dibagi menjadi kelompok anak GSA (15 orang) dan kelompok anak normal (15 orang) yang dicocokkan dengan usia dan jenis kelamin (matching). Derajat keparahan GSA dinilai dengan skor Child Autism Rating Scale (CARS) yang diisi oleh psikiater anak. Selain itu juga dilakukan analisis korelasi antara kadar malonildialdehid (MDA) serum dengan skor CARS pada anak GSA. Hasil: Rerata kadar MDA serum anak GSA (34,60 nmol/mL±4,99nmol/mL) lebih tinggi dibandingkan dengan anak normal (31,12 nmol/mL±3,44 nmol/mL); p=0,035. Terdapat perbedaan bermakna kadar MDA serum antara kelompok GSA dengan derajat ringan-sedang dan berat (p=0,005). Kadar MDA serum berkorelasi positif dengan skor CARS pada anak GSA (r=0,52) Kesimpulan: Kadar MDA meningkat pada anak GSA. Peningkatan kadar MDA sebagai biomarker stres oksidatif pada anak GSA berkorelasi dengan peningkatan skor CARS yang menunjukkan derajat keparahan GSA. J Indon Med Assoc. 2013;63:224-9.

Introduction: The purpose of this research was to identify the correlation between the level of serum malonyldialdehyde (MDA) as a marker of oxidative stress in children with Autism Spectrum Disorder (ASD) and normal (non-ASD) children, as well as to analyze the correlation between the level of serum MDA and the score of Child Autism Rating Scale (CARS) that used to assess the severity of ASD in children. Method: This is a case-control study involved 15 children with GSA in case group and 15 normal children in control group, which matched for age and gender. The severity of ASD was assessed using CARS, This questionnaires were filled in by child psychiatrist. Correlation between serum malonyldialdehyde (MDA) and the sore of CARS in ASD children were also examined. Result: Mean of serum MDA level in ASD children (34,60 nmol/mL±4,99nmol/mL) was higher than normal children (31,12 nmol/mL±3,44 nmol/mL);p=0,035. There were a significant difference between the levels of serum MDA in mild-moderate ASD children and severe ASD in children based on the score of CARS (p=0,005). There was a significant correlation between serum MDA levels and CARS scores in ASD children (r=0,52) Conclution: Serum MDA level were higher in ASD children. The increased levels of serum MDA as a biomarker of oxidative stress correlates with an increased of CARS scores that indicates of the severity of ASD.