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Association between mRNA Expression of Aromatase, 17ß-HSD2, Level of TGF-ß1 and Stage of Endometriosis

Association between mRNA Expression of Aromatase, 17ß-HSD2, Level of TGF-ß1 and Stage of Endometriosis
Ruswana Anwar, Firman F. Wirakusumah, Duddy S. Nataprawira, Ani M. Maskoen, Wiryawan Permadi, Tono Djuwantono
Universitas Padjadjaran, Open Journal of Obstetrics and Gynecology, 2016, 6, 411-418 Published Online June 2016 in SciRes. https://www.scirp.org/journal/ojog, https://dx.doi.org/10.4236/ojog.2016.67054
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Universitas Padjadjaran, Open Journal of Obstetrics and Gynecology, 2016, 6, 411-418 Published Online June 2016 in SciRes. https://www.scirp.org/journal/ojog, https://dx.doi.org/10.4236/ojog.2016.67054
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Aim: To identify the correlation between mRNA expression of aromatase, 17ß-HSD2 level of TGF- ß1and stage of endometriosis. Methods: Case control study was done on 80 patients divided by 40 endometriosis patients and 40 patients as control. mRNA expression of aromatase, mRNA 17ß- SD2, was checked using reverse-transcriptase polymerase chain reaction (RT-PCR) and TGF-ß1 serum and peritoneal fluid was checked using ELISA. Result: Level of mRNA aromatase from ectopic and eutopic endometrium increased significantly compared to control group (p < 0.001). mRNA 17ß-HSD2 expression is significantly lower compared to control (p < 0.001). Level of TGF- ß1 on en- dometriosis group was significantly higher compared to control group (p < 0.05). Level of peritoneal fluid TGF-ß1 on endometriosis group was higher than control group (p < 0.001). There are no correlations between mRNA aromatase, type 2 17ß-HSD, TGF-ß1 serum level to endometriosis stage. There are significant correlations between peritoneal fluid TGF-ß1 levels to endometriosis stage.

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