Abstrak 
Primary Cutaneous Diffuse Large B Cell Lymphoma, Leg Type Of The Hemithoraks Lateral Dekstra That Firstly Diagnosed As Primary Cutaneous Follicle Centre Lymphoma
Bethy S. Hernowo, dr. ,Sp.PA(K).,Ph.D
Universitas Padjadjaran, Dibawakan pada Annual Scientific Meeting 2013; Advances and Better Approaches to Lymphoma and Cytopathology Diagnosis
Bahasa Inggris
Universitas Padjadjaran, Dibawakan pada Annual Scientific Meeting 2013; Advances and Better Approaches to Lymphoma and Cytopathology Diagnosis
Primary cutaneous diffuse large B-cell lymphoma
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is one of the main types of primary cutaneous B-cell lymphoma with characteristic clinicopathological and immunohistochemical features represents 1-4% of all cutaneous lymphomas proximately 1020% of all PCBCLs and it seems that is increasing in frequency. The disease predominantly affects elderly patients (median age in the 70s), especially females, with the male to female ratio ranging from 1:2 to 1:4. Typically, patients present with rapidly growing, solitary or clustered, red or bluish-red nodules or tumors located on one or both legs, which can ulcerate. However, in 10-20% of the patients, lesions arise at other body sites for the initial manifestation . These lymphomas are mostly limited to the skin at presentation. However, the most frequent extracutaneous sites that are spread are the lymph nodes, the bone arrow, and the central nervous system. PCDLBCL-LT is an intermediate-grade B-cell lymphoma with 5-year survival rates ranging from only 41 % up to 73 %. Therefore, appropriate treatment decisions are required. We present an interesting case of PCDLBDL-LT, that firstly diagnosed as PCFCL with multiple relapse after first line chemotherapy.