Abstrak 
Analyzing the Interaction of Shellegueain A, a Bioactive Compound of Pakis Tangkur (Selliguea feei or Polypodium feei) to Cyclooxygenase Enzyme by Molecular Docking
Analyzing the Interaction of Shellegueain A, a Bioactive Compound of Pakis Tangkur (Selliguea feei or Polypodium feei) to Cyclooxygenase Enzyme by Molecular Docking
Aliya Nur Hasanah, Jutti Levita, Elfandari Dewi Natapoera, Anas Subarnas
Universitas Padjadjaran, Asian Journal Of Chemistry Vol 23, No. 7 2011
Bahasa Inggris
Universitas Padjadjaran, Asian Journal Of Chemistry Vol 23, No. 7 2011
Afzelechin, Cydooxygenase, molecular docking, Selliguea feei, Shellegueain A
Aliya Nur Hasanah, Jutti Levita, Elfandari Dewi Natapoera, Anas Subarnas
Universitas Padjadjaran, Asian Journal Of Chemistry Vol 23, No. 7 2011
Bahasa Inggris
Universitas Padjadjaran, Asian Journal Of Chemistry Vol 23, No. 7 2011
Afzelechin, Cydooxygenase, molecular docking, Selliguea feei, Shellegueain A
Shellegueain A is an active compound contained in pakis tangkur (Selliguea feei or Polypodium feei). This compound has been proven to show analgesic activity by decreasing writhing response in acetic acid-induced rats. It also showed antiinflammatory activity by signifi-candy reducing oedema in carrageenan-induced rat’s paw. The purpose of this study was to examine the binding modes of shellegueain A against COX-1 and COX-2 in terms of hydrogen bonds and docking energy, to understand its analgesic and antiinflammatory properties. The simulation indicated that shellegueain A did not interact with either COX- I or COX-2 enzymes, while afzelechin (a monomeric metabolite of shellegueain A) did by making hydrogen bonds with Met522.
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