Abstrak 
Anticancer properties of daily-consumed vegetables Amaranthus spinosus, Ipomoea aquatica, Apium graveolens, and Manihot utilisima to LNCaP prostate cancer cell lines
Cristine D. Octaviani, Melinda Lusiana, Ade Zuhrotun, Ajeng Diantini, Anas Subarnas, Rizky Abdulah
Universitas Padjadjaran, Journal of Natural Pharmaceuticals, Volume 4, Issue 1, January-June, 2013
Bahasa Inggris
Universitas Padjadjaran, Journal of Natural Pharmaceuticals, Volume 4, Issue 1, January-June, 2013
brine shrimp lethality test, LNCaP. methyl thiazolyl tetrazolium assays, Prostate cancer
Introduction: Prostate cancer is the second most common cancer in men worldwide. Efforts on finding potential sources from daily consumed foods that inhibit prostate cancer development are becoming important objective for scientists. Previous epidemiologic studies have consistently shown that consumption of fruit and vegetables was found to have significant contribution in the prevention of cancer. Thus in this study, we investigated the anticancer potency of popular vegetables consumed in Indonesia, namely, Amaranthus spinosus, Ipomoea aquatica Forsk., Apium graveolens L., and Manihot utilisima to Lymph Node Carcinoma of the Prostate (LNCaP) human prostate cancer cell lines. Materials and Methods: The extracts were tested for Brine shrimp lethality test to guide their cytotoxic potencies, and methyl thiazolyl tetrazolium assay to LNCaP cells for their anticancer properties. Results: The results showed that I. aquatica Forsk has the most potential anticancer sources, with LC50 against Artemia saline and Inhibition Concentation (IC)50 against LNCaP being 266 pg/rnL and 400 tg/mL, respectively. Conclusions: Our preliminary result suggest that I. aquatica Forsk. has the potential to be further investigated and developed as anticancer sources.