Abstrak 
Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway
Ajeng Diantini, Anas Subarnas, Keri Lestari, Eli Halimah, Yasmiwar Susilawati, Supriyatna, Euis Julaeha, Tri H. Achmad, Eka W. Suradji, Chiho Yamazaki, Kenji Kobayashi, Hiroshi Koyama, Rizky Abdulah
Universitas Padjadjaran, ONCOLOGY LETTERS 3: 1069-1072, 2012, Received December 12, 2011; Accepted January 30, 2012, DOI: 10.3892/ol.2012.596
Bahasa Inggris
Universitas Padjadjaran, ONCOLOGY LETTERS 3: 1069-1072, 2012, Received December 12, 2011; Accepted January 30, 2012, DOI: 10.3892/ol.2012.596
Apoptosis, Cancer, caspase, primates, Schima wallichii
Plants consumed by non-human primates represent potential drug sources for human disease management. In this study, we isolated kaempferol-3-O-rhamnoside as an active compound from the leaves of Schima wallichii Korth., a plant commonly consumed by non-human primates. Its anti-cancer activities, including its ability to induce apoptotic mecha¬nisms, were investigated in MCF-7 breast cancer cells. Results showed that in MCF-7 cells, kaempferol-3-O-rhamnoside inhibits cell proliferation in a dose-dependent manner and promotes apoptosis via the activation of the caspase signaling cascade, which includes caspase-9, caspase-3 and PARP. Our results provide a basis for further exploration of kaempferol¬3-O-rhamnoside as an active compound for potential anti-cancer therapeutics.