Abstrak 
Comparison of Pro B-natriuretic Peptide in Hypertensive Patients with and without Diastolic Dysfunction
Yudistira P. Santosa, Anna Tjandrawati, Noormartany, Erwinanto, Ahmad F. Yahya, Erwan Martanto, Pintoko Tedjokusumo, Augustine Purnomowati, Eko Antono
Universitas Padjadjaran, Acta Med Indones-Indones Journal Intern Med Vol 40, Number 1, January 2008
Bahasa Inggris
Universitas Padjadjaran, Acta Med Indones-Indones Journal Intern Med Vol 40, Number 1, January 2008
diastolic dysfunction, hypertension, pro B- Natriuretic peptide
Aim: to evaluate whether pro BNP can be used for detection of diastolic dysfunction. Methods: thirty nine hypertensive patients with normal systolic function, consecutively referred for echocardiography examination between October and December 2004 were recruited in the study. Diastolic dysfunction was diagnosed when echocardiographic mitral ?ow pattern demonstrated impaired relaxation, pseudonormalization or restrictive like patterns. NT-pro BNP levels were assessed using electro chemiluminescence Immunoassay (ECLIA) method. Unpaired t test was used to analyze the results. Results: twelve out of thirty nine subjects had normal diastolic function. All base line characteristics, except for uric acid, were equally distributed between normal and abnormal diastolic function group. NT-pro BNP levels were nearly signi?cantly higher in the diastolic dysfunction group (P=0.053). Conclusion: NT-pro BNP levels trends to be higher in hypertensive subjects with diastolic dysfunction.