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Dissolution Profile Of Theophylline Extended Releasecaplets Based On Metolose 90sh – 4000sr With Accelerated Stability Study

Dissolution Profile Of Theophylline Extended Releasecaplets Based On Metolose 90sh – 4000sr With Accelerated Stability Study
Marline Abdassah, Yoga Windhu Wardhana,Dradjad Priambodo, Richie A. I. Chandra, Yedi Herdiana, Anis Ch.
Universitas Padjadjaran, Actapharmica (2015) Vol.2 (1) 88-92, ISSN 2386-8937
Bahasa Inggris
Universitas Padjadjaran, Actapharmica (2015) Vol.2 (1) 88-92, ISSN 2386-8937
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To avoid consume theophylline oftenly, we need an extended release dosage form to maintain the therapeutic dose on the blood plasma for a long interval time. The most common dosage form in the market is coated tablet, but that needs a long procedure and quite expensive to be produced. Recently, there is a brand new polymer derived from Hydroxypropylmetyl cellulose is Metolose 90SH-4000SR. This kind of polymer is able to form high viscosity hydro gel with a suitable solvent. Gel which is formed from the polymer physically restrain the active ingredient released on a short period. Through this study, presented practically easy to use metolose as the matrix of a binder in wet granulation method. The study found that efficient solution consistency for binder solution of the matrix gel of Metolose is 10%. In the manufacturing process of the caplets, metolose as gel is used on low concentration at 4,5-5% (18-20 mg of 400 mg total weight of caplet). Both caplets shows similiar quality in terms of physical properties and dissolution rate profile. After 6 months storage at 40 OC and humidity 75% (accelerated stability condition storage) the dissolution profile and theophylline contents not change or decrease significantly.

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