Abstrak 
Enhancement Effect Of DMSO And Ethyl Acetate On Piroxicam Permeation In Acupec HV-505 GELS*)
Marline Abdassah, Anis Yohana Chaerunisaa, Mutakin
Universitas Padjadjaran, Presented in International Conference on Mathematics and Natural Sciences, Institut Teknologi Bandung, November 29-30th, 2006.
Bahasa Inggris
Universitas Padjadjaran, Presented in International Conference on Mathematics and Natural Sciences, Institut Teknologi Bandung, November 29-30th, 2006.
DMSO, enhancer, Ethyl acetat., gel, Piroxicam
Gel formulation of piroxicam 0.5 % was prepared using Aqupect HV 505 1 % as a base and DMSO or ethyl acetate as an enhancer. The concentrations of enhancer were 5, 7.5 and 10 % for ethyl acetate and 3, 5 and 7 for DMSO. The physical stability (organoleptic, pH, viscosity, consistency) and drug content during 56 days storage were investigated and the results showed that all gel formulas had good stability. The permeation rate of piroxicam was investigated using the rat abdominal skin as a membrane. Based on experimental results, both the ethyl acetate and DMSO gave significant enhancement on piroxicam permeation as compared with control. Piroxicam gel with DMSO 5% gave the best enhancement effect (8.9 %) and that with aethyl acetate 5 % gave enhancement of 8.0 % while the control gave 7.6 % .