Abstrak 
Correlation between DepotmedroxyprogesteroneAcetate (DMPA) Use and Bone Mineral Density in Reproductive Women Age
Muhammad Alamsyah Aziz, Dudy S.N., Tono Djuwantono, SofieRifayani Krisnadi, Udin Sabarudin,Wiryawan Permadi, Riesa K. W. Rohmat
Universitas Padjadjaran, International Journal of ChemTech Research CODEN (USA): IJCRGG, ISSN: 0974-4290, ISSN(Online):2455-9555 Vol.10 No.1 pp 356-366, 2017
Bahasa Inggris
Universitas Padjadjaran, International Journal of ChemTech Research CODEN (USA): IJCRGG, ISSN: 0974-4290, ISSN(Online):2455-9555 Vol.10 No.1 pp 356-366, 2017
BMD, DMPA users, length of DMPA use.
Background: Depomedroxyprogesteron acetate (DMPA) is the most popular contraception in the world. The used of this contraception can be caused osteoporotic. Objective this research was to compare the bone mineral density (BMD) of DMPA users and non-users, and its correlation with the length of use DMPA. Methods: Cross-sectional study was done on 32 DMPA users and 31 non-users as control, who met the inclusion criteria, at Department of Obstetrics and Gynecology Hasan Sadikin General Hospital, from January to December 2005. To be noted: age, height, weight, body mass index (BMI), marital age, parity, graduated marital status, and ethnicity. Analysis was done by chisquare test, t-test, exact Fisher test, Mann-Whitney test, and rank Spearman correlation analysis. Results: Characteristics of DMPA users were: (28.8 + 4.9) years, height (154 + 4.8) cm, weight (51.2 + 7.1) kg, body mass index (21.5 + 2.7) kg/m2, marital age (20.8 + 3.8) years, parity >1(96.87%), senior high school (56.25%), married (96.87%) and sundanese (100%), and on the control group were: age (32.8 + 4.2) years, height (154.3 + 5.1) cm, weight (53.4 + 9.7) kg, BMI (22.4 + 3.7) kg/m2, marital age (23 + 3.4) years, parity >1 (87.1%), senior high school (51.62%), married (93.55%), and sundanese (100%). The characteristics in both groups were homogeneous (p>0.05). The average of BMD in both group was significantly different (p<0.001), (1.025 + 0.394) g/cm2 versus (1,184 + 0.0166) g/cm2. The difference between each measured value was 0.159 g/cm2. The mean length of DMPA use was (54.8 + 33.8) months and its correlation with bone mineral density (BMD) was significantly different (p>0.05). The correlation between DMPA use and BMD was very significant (p<0.001) in the youngest group (20-24 years), but there was no significant correlation between body mass index (BMI) and BMD (p>0.05). Conclusions: BMD in DMPA users is lower than that in non-users. There is no correlation between the length of DMPA use and the BMD.