Abstrak 
Psidium Guajava L. Extract Increases Platelet Count Through Enhancement Of Stem Cell Factor Expression In Thrombocytopenic Mice Model
Nur Atik, Susan Tarawifa, Erda Avriyanti, Andri Reza Rahmadi, Dany Hilmanto
Universitas Padjadjaran, International Journal of Pharmacy and Pharmaceutical Sciences Vol 10, Issue 1, 2018 , ISSN- 0975-1491
Bahasa Inggris
Universitas Padjadjaran, International Journal of Pharmacy and Pharmaceutical Sciences Vol 10, Issue 1, 2018 , ISSN- 0975-1491
Guava extract, Platelet, Stem cell factor, Thrombopoietin
Objective: The purpose of this study was to determine the mechanism through which guava extract increases platelet count. Methods: Twenty male Swiss webster mice were divided into 4 group. Group I received 2.8 mg/20 g body weight of quinine and 1 ml of distilled water. Group II received 2.8 mg/20 grBW of quinine and 0.785 mg/20 grBW of guava extract. Group III received 1 ml distilled water and 0.785 mg/20 grBW of guava extract and Group IV only received 1 ml distilled water. After 14 days** treatment, platelet count was measured using RaasEcker method. SCF and TPO mRNA expressions in mice liver were assessed using qRT-PCR. Results: The data showed that quinine administration reduced platelet count significantly (P<0.05). Psidium guajava L. extraction significantly enhanced platelet count in mice that were treated with quinine compared with quinine group (p<0.05). The mechanism was analysed further and our RT PCR data showed that stem cell factor mRNA expression significant increased (p<0.05) in quinine plus guava extract group compared to quinine group. Conclusion: It indicated guava extract role in increasing megakaryopoiesis which resulted in an increase of platelet count.