Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Formulation And Stability Evaluation Of Atenolol Emulgel

The purpose of this study is to formulate and evaluate stability of atenolol emulgel in two gel bases to which Viscolam MAC 7 and Aqupec HV 505 using various concentration of emulsion system. Evaluation on stability included organoleptic; to which colour, smell, consistency, homogeinity and bleeding, and examination on pH, viscosity and globule diameters by Freeze-thaw method during 35 days of storage. Qualitative analysis was conducted into emulgel by Thin Layer Chromatography (TLC) while quantitative analysis was conducted by spectrophotometry. Stability evaluation on viscosity and drug content gave results that FB2 and FB4 more stable compared with other six formulas. Both formulas didn’t give irritation to skin.