Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Release Of Propranolol Hcl As Drug Combination From Matrix Tablet System

The purpose of the research was to study the release of propranolol HCl as model of highly soluble drug in matrix tablet system as drug combination. Tablets were prepared by direct compression method. Alternatively, propranolol HCl was granulated with Ethocel 10 cP (1:1) using isopropanol:water (88:12 w/w) prior the mixing and compression. The granulation were conducted either conventionally by high shear method or using fluid bed granulator. Another approach was by direct compression of blends containing propranolol HCl coated pellets and other excipients. Drug release was performed in a USP paddle apparatus in phospate buffer pH 6.8. The results showed that using direct compression method, propranolol HCl was released fast because of its high solubility. It was released rapidly from Ethocel® 10cP based matrix tablets and was extended from Methocel® K15M based tablets. Applying Methocel as polymer matrix showed that Granulation of propranolol in fluid bed granulator extended the release to more than 18 h. It can be concluded that Fluid bed granulation method prior to compression as matrix tablet provided highest retardation of propranolol HCl in matrix tablet system.