Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Chondroitin in Transdermal Patch and Its Main Physical Properties

Kondroitin Sulfat (CS) dalam bentuk sediaan oral telah digunakan untuk membantu mengelola Osteoarthritis,namun ketersediaan hayatinya sangat rendah yaitu hanya 13%, hal ini disebabkan oleh efek lintas pertama di hati dan untuk menghindarinya diperlukan formulasi CS ke dalam bentuk sediaan lain seperti patch. Penelitian ini bertujuan untuk mengetahui kemungkinan Kondroitin Sulfat (CS) untuk diformulasikan dalam patch transdermal secara in-vitro dan dikarakterisasi sifat fisik seperti profil permeasi melalui studi Franz’s Cell dan koefisien partisi. Penelitian menunjukkan bahwa 150 mg CS dalam sediaan patch transdermal memberikan permeasi konstan dalam waktu 19 jam dengan koefisien partisi 2,22. Berdasarkan profil permeasi dan studi koefisien partisi, patch CS akan menjadi sediaan efektif untuk dipertimbangkan.

Chondroitin Sulphate (CS) in oral dosage form has widely used to help manage Osteoarthritis, but regret its bioavailability was very low at only 13%, It was due to the first passed effect in the liver and to avoid it CS is needed to be formulated into another forms of preparation like Patch. This study was aimed to figure out in-vitro possibility of Chondroitin sulphate (CS) to be formulated in a Transdermal patch and characterized by its physical properties such as permeation profile through the Franz’s Cell and partition coefficient studies. The study showed that 150 mg CS in Transdermal patch given the constant Permeation within 19 hours with the Partition Coefficient of 2.22. Based on the permeation profile and the partition coefficient study, the CS patch would become an effective preparation to be considered