Abstrak 
Simvastatin-nicotinamide Co-crystal: Design, Preparation And Preliminary Characterization
Iyan Sopyan, Achmad Fudholi, Muchtaridi Muchtaridi, Ika Puspita Sari
Universitas Padjadjaran, Tropical Journal of Pharmaceutical Research February 2017; 16 (2): 297-303, ISSN: 1596-5996 (print); 1596-9827 (electronic), Available online at https://www.tjpr.org, https://dx.doi.org/10.4314/tjpr.v16i2.6
Bahasa Inggris
Universitas Padjadjaran, Tropical Journal of Pharmaceutical Research February 2017; 16 (2): 297-303, ISSN: 1596-5996 (print); 1596-9827 (electronic), Available online at https://www.tjpr.org, https://dx.doi.org/10.4314/tjpr.v16i2.6
Co-crystal, dissolution, Nicotinamide, Simvastatin, solubility
Purpose: To improve the solubility of simvastatin (SV) by co-crystallization using nicotinamide (Nic) as co-crystal agent (co-former). Methods: In silico molecular modeling of Nic counter to SV were investigated using Auto Dock 4.2. Cocrystal of Nic-SV was obtained by solvent evaporation (SE) using an equimolar ratio of Nic and SV. Cocrystal of SV-Nic was evaluated by scanning electron microscopy (SEM), saturated solubility, intrinsic dissolution, x-ray powder diffraction (XRPD), differential scanning calorimetric (DSC), infrared spectrophotometry (FT-IR), binary phase diagram, and for stability at 40 oC and relative humidity (RH) 75% in one month. Results: In silico results showed that the interaction of Nic with SV took place through hydrogen bonding as the synthon agent. The solubility and intrinsic dissolution properties of the co-crystal improved significantly compared to pure SV. Characterization of the co-crystal SV: Nic (1: 1) by SEM, XRPD, DSC, FT-IR, and binary phase diagram indicate the formation of a new solid phase that was different from either SV or Nic. Furthermore, the cocrystal of SV: Nic remained stable for one month. Conclusion: Co-crystallization using Nic has the potential to enhance drug solubility, intrinsic dissolution, and the stability of solution.