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Immunomodulatory Activity of Solanum Torvum Ethanolic Extract on Infected Wistar Rats
Syamsudin R., Aldizal M.R., Barliana Melisa I., Zuhrotun Ade, Moektiwardoyo Moelyono
Universitas Padjadjaran, Research Journal of Chemistry and Environment Vol. (Special Issue I) January (2018), The 2nd International Seminar and Expo on Jamu September 26th-27th, 2017, Bandung-Indonesia
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Universitas Padjadjaran, Research Journal of Chemistry and Environment Vol. (Special Issue I) January (2018), The 2nd International Seminar and Expo on Jamu September 26th-27th, 2017, Bandung-Indonesia
flow cytometry, immunomodulatory, Solanum torvum
Immunomodulators are compounds that alter the activites of immune system that had a vital role in preventing diseases. Takokak or Solanum torvum Swartz is empirically known as immunomodulator by its secondary metabollites such as flavonoids and poliphenols. This study was conducted to determine the effect of takokak fruits ethanolic extract against parameters of immunity such as the number of leucocyte with its components in Wistar rat strain using inducted by Shigella dysentriae. Extract was given orally for 16 days at a dose of 250 mg/kg BW and 500 mg/kg BW. S. dysentriae was inducted on day -7, and -14. Then, blood sampling was conducted on day 0, 7, 9, 14 and 16 then compared to positive, and negative controls. Blood samples were observed using flow cytometry method by flow cytometer instrument. Immunomodulatory activity was observed through changes in numbers of leukocytes components. The result showed an immunomodulatory effect showed by leukocytes, lymphocytes and monocytes alteration in treated group which means that takokak had an immunomodulatory activity in Wistar rats.