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Cytototoxic Constituents From The Bark Of Chisocheton Cumingianus (Meliaceae)

Cytototoxic Constituents From The Bark Of Chisocheton Cumingianus (Meliaceae)
Dewa Gede Katja, Kindi Farabi, Nurlelasari, Desi Harneti, Tri Mayanti, Unang Supratman, Khalijah Awang, Hideo Hayashi
Universitas Padjadjaran, Journal of Asian Natural Products Research 2016, ISSN: 1028-6020 (Print) 1477-2213 (Online) Journal homepage: https://www.tandfonline.com/loi/ganp20, https://dx.doi.org/10.1080/10286020.2016.1196671
Bahasa Inggris
Universitas Padjadjaran, Journal of Asian Natural Products Research 2016, ISSN: 1028-6020 (Print) 1477-2213 (Online) Journal homepage: https://www.tandfonline.com/loi/ganp20, https://dx.doi.org/10.1080/10286020.2016.1196671
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A new lanostane-type triterpenoid, 3ß-hydroxy-25-ethyl-lanost9(11),24(24′)-diene (1), along with 3ß-hydroxy-lanost-7-ene(2) and ß-sitosterol-3-O-acetate (3) was isolated from the stem bark of C. cumingianus. The chemical structure of the new compound was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-3 showed cytotoxicity against P-388 murine leukemia cells with IC 50 values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 µg/ml, respectively.

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