Abstrak 
Cytotoxic Steroids From The Bark Of Aglaia Argentea (Meliaceae)
Kindi Farabi, Desi Harneti, Nurlelasari, Rani Maharani, Ace Tatang Hidayat, Unang Supratman, Khalijah Awang, Yoshihito Shiono
Universitas Padjadjaran, Chiang Mai University Journal of Natural Sciences (2017) Vol. 16(4), EISSN 2465-4337, https://doi.org/10.12982/CMUJNS.2017.0024
Bahasa Inggris
Universitas Padjadjaran, Chiang Mai University Journal of Natural Sciences (2017) Vol. 16(4), EISSN 2465-4337, https://doi.org/10.12982/CMUJNS.2017.0024
Aglaia argentea, Cytotoxic activity, Meliaceae, P-388 murine leukemia cells, Sterol
The study aimed to find a potential anticancer agent by isolating and identifying the chemical structure of compounds from Aglaia argentea and testing their cytotoxic effects against P-388 murine leukimia cells. Five steroids – stigmast-5-en-3ß-ol (ß-sitosterol) (1), stigmast-5-en-3ß-ol-3ß-oleate (ß-sitosterol oleate) (2), stigmast-5-en-3ß-ol-3-O-(6′-O-oleoyl)-ß-D-glucopyranoside (sitoindoside II) (3), stigmast-5-en-3ß-ol-3-O-ß-D-glucopyranoside (ß-sitosterol glucoside) (4), stigmast-5,22-dien-3ß-ol-3-O-ß-D-glucopyranoside (stigmasterol glucoside) (5) – were isolated from the bark of Aglaia argentea. The chemical structures of 1-5 were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY) and HRTOFMS, as well as by comparing with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-5 showed cytotoxicity against P-388 murine leukemia cell with IC 50 values of 12.45 ± 0.050, 85.25 ± 0.050, >100, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.